Such conclusion has drawn international team of scientists from the University of Toronto, Harvard School of Public Health and the University of Costa Rica, after research with 4,028 Costa Ricans. Caffeine, which is a part of coffee, is transformed by means of liver enzyme cytochrome P450 1A2 (CYP 1A2). Depending on the version of a gene, which controls the work of these enzymes, the splitting of caffeine by different people can be faster and slower.

The study included 2014 Costa Ricans, who transmitted one myocardial infarction, and 2014 Costa Ricans, who do not suffer from heart diseases. All participants answered questions related to frequency of coffee consumption. They also carried out genetic tests to determine the specific variant of gene CYP 1A2.

Genetic tests have shown that «slow» variant of gene had 55% of people experienced heart attacks and 54% of people from the control group.

By people with «slow» variant gene, who drank 2-3 cups of coffee per day, the risk of myocardial infarction was 36% higher than those who drank less than 1 cup of coffee. With the use of 4 or more cups of coffee per day the risk of heart attack rose to 64%. People elder than 50 were in the most danger.

By people with «fast» variant gene, who drank up to 3 cups of coffee per day, the risk of heart attack was even lower than by people who used less than 1 cup per day, but with doses increasing this effect was not observed.

«One cup of coffee per day do not do any harm, not depending on genetic features», – considers the author of study Ahmed el-Sohemy. More coffee volume can be harmful or harmless, but people who do not know which version of the gene they have, the best of all would be to observe moderation

The scientists of The University of Barcelona have performed a research with 668 healthy volunteers. At first they were asked to drink coffee with caffeine and then without it. A cup of espresso, which was taken at the beginning, had a restorative effect already in 10 minutes.

By that, in order to reach maximum caffeine concentration in the blood, human’s body needs 45 minutes, but half of participants got concentration after just a few minutes.

The decaf coffee had a similar effect (exactly which contains 5mg of this substance). In both cases, researches have marked the most rapid effect achievement by men than by the weaker sex.

“The stimulant effect of caffeine has been proved by a numerous studies, but none of these have looked at their effects in terms of the consumer’s gender”, – said lead researcher Ana Adan.

“This study provides an interesting insight into how the effects of specific foods and nutrients may differ between men and women. Research into ‘gene-nutrient’ interactions gives more and more results. We can see how our genetic data affects our requirements for certain foods and nutrients, and how our bodies react to these. In the future this could allow scientists to formulate dietary recommendations based on our genetic data, as well as our age and body size”, – added Anna Denny from the British Nutrition Foundation.

In order to reach maximum caffeine concentration in the blood, human’s body needs 45 minutes, but for somebody just a few minutes will be enough.

Now some words about science. The fiber is impregnated with caffeine microcapsules. The body temperature makes caffeine affect the skin. It has been proved that caffeine’s active components stimulate metabolism, burn fats and strengthen leg tissue.

But it is obvious that tights which in a few years become quite usual, will not be a miracle treatment. «If people think that they can wear some pair of tights and then eat plenty of cakes with cream, and at the same time stay beautiful – its only dreams», said Amanda Vinn from the British Association of Dietology in interview to Guardian.

However with a warm day approaching, when you want to walk with naked legs, now it’s the very time to test new tights. Or you can simply pour out coffee on the legs, it will be more cheaper, because a pair of tights with a secret will cost you 27 pounds sterling. But if you prefer fresh coffee, wait for a while, until its get cold, and only then pour it on your legs – weight loss by means of burn wasn’t recommend to you.

Taking into account the beneficial effect from caffeine usage, official sports organizations, as International Olympic Committee, have determined a fixed norm which isn’t considered as a dope. The permissible dose is 5-8 cups of coffee or equivalent number of caffeine taking shortly before the competition.

Coffee and creation

With admiration wrote about coffee Balzac in «Treatise about modern analeptics»:
«As soon as coffee gets stomach, at once appears excitement. Thoughts start moving like Great Army’s battalions on the battlefield. Instantly in a memory arise events quasi adapt with a wind.»

Coffee like a medicine

In Europe at first coffee beans were considered like a remedy, and they rapidly have been moved from botanist’s study to drugstores. In XVII century in medicaments` assortment of doctors, homoeopathists, chemists and even obstetricians, they took honorary place.

Coffee was considered like a medicine not only because of its high cost, but rather of its pronounced specific taste. Sometimes it was even called as bitter black liqueur. (Samuel Hahnemann homoeopathy’s founder, stuck to hard and fast rule: «Coffee – is definitely medical substance. However no one remedy has more healthy taste than strong coffee without sugar. Even from the first time it seems everyone very pleasant»).

The doctrine of vital juices, which was developed by Galen (131—200), adherent of herbage therapy, has dominated in medieval Europe and also in Moslem countries. According to his theory, the physical state of any person is determined by means of four liquids: yellow and black bile, phlegm and blood. By disturbance of their correlation in organism appears disease. In its turn, each of vital juices is connected with two physical properties: warm (cold) and moisture (dryness). It was considered that these qualities have food, drink and medicines; just they were used for restorer of equilibrium of vitally important liquids.

Concerning medicinal properties doctors did not have consensus of opinion. Some of them were sure that it is dry and cold, other believed – dry but hot. It was such opinion that qualities of husk are different. The disunity in the ranks of physicians becomes obvious, if examine the list of diseases where coffee was prescribed.

In one of the brochures, written in 1663 and ridiculed doctors at the time, were some examples of people (and their places of residence), who recovered from the ailments (using coffee), when they were refused by doctors. Among them, Benjamin Bedkock who drank coffee in Leiden, and his wife, who was barren for four years. A nine months later after she denied from coffee, she bore excellent baby. «Anna Marina Rotterdam … was suffered from the tumor on her upper lip … and the deeper it was cut out, the longer it grew. As soon as she started to drink coffee, tumor turned back and began to grow inside the mouth».

One of the French doctor in collaboration with his colleagues, have determined that coffee together with others therapeutic effects can counteract drunkenness and subdue sickness, as well as relieve urination and treat dropsy, pox and gout. According to French encyclopaedia «Larousse», coffee is especially useful for writers, soldiers, sailors and workers, who are working in hot shops. For a wonder it is also useful for countries where cretinism is widespread.

Coffee like stimulator

Some consequences of caffeine’s effect cannot fail to be seen. One of the recognized medicine authorities gives following description: “Waking up, I feel languor and absence of some thoughts, like an oyster. However after drinking coffee, my memory becomes more sensitive, and I feel talkativeness, quickness and thirst for activity. We should drink coffee observing moderation and caution”.

A favourable report about coffee drink gave doctor Tornton: «A cup of strong coffee strengthens our mental and physical faculties. There aren’t any efficient remedies both for scientists and for workers».

As a result, useful substances from coffee beans are received human skin.

The record of coffee wholesome influence on mental and creative work can be found in proceedings of great writers. Honoré de Balzac, Émile Zola, Charles Pierre Baudelaire, Jean-Baptiste Moliere, François Voltaire were coffee admirers. In response to the fact that coffee isn’t a powerful but poison, Moliere and Voltaire, as one, answered that they have been drinking coffee during fifty years, and even if it had been quite weak, they would died long ago.

However doctors mentioned some negative consequences of coffee passion. (Hahnemann described so-called «coffee disease», which becomes apparent in the form of indisposition, collapse and special paralysis. Among others undesirable symptom were melancholy, haemorrhoids, headaches and diminished sexual libido (hypoactive desire).

It was an opinion that coffee had a bad influence on little children. Nursing mothers also should not drink it. It was considered that it ruins teeth and develops rickets.

The author of many medical treatises, a famous Italian doctor Sinibaldi, was a coffee opponent. He confirmed: „The commerce, which is developed between Asia and the New World, lead to smallpox development. What is more important, it introduced us a new beverage, which has destructive effect… It leads to intellectual defect, change of digestive juices, indigestion, convulsions, toe paralysis and giddiness. “

The disputes about the pros and cons of coffee have been continued for many years. With varying degrees doctors considered it sometimes a medicine, sometime a poison for the mind and body. They do not reach a consensus at present time.

Coffee and healthy skin.

In Japan, where during a thousand years traditional drink was green tea, coffee was spread very slowly. It was imported there not earlier then XIX century, and even nowadays its popularity is not wide.

However just in this country coffee has found unusual use. Japanese believe that coffee contains substances which are useful for skin recovery.

Health Benefits From Coffee

According to BBC, doctors from the Radboud University in Nijmegen, Netherlands, under the direction of Bea Linsten, have found that coffee consumption reduces fertility by women, who had had problems with conception. Scientists kept under observation over 9 thousand of patients, who have used the in vitro fertilisation (IVF) procedure from 1985 to 1995. 16% of them were able to become pregnant naturally after IVF hormone therapy. The subject of investigation was the lifestyle and food habits of women. It turned out that the use of four or more cups of coffee per day for 26% reduces the probability to become pregnant.

The usage of alcohol at least three times a week to the same extent reduces these chances, and smoking (even if the matter concerns one cigarettes per day) in combination with excess weight reduces the reproductive performance of women. For example, 36-year-old woman, who is smoker and coffee-lover, with excess weight, three times resorted to IVF, has naturally probability of pregnancy only at 5%. In normal weight and the absence of three other risk factors with the same woman, her chances of getting pregnant are 15%.

Coffee gel-scrub perfectly splits subcutis, excretes toxins, fights with cellulitis. Simultaneously it guarantees the invigorative effect, because coffee’s smell stimulates nervous system activity. It means you can exclude a cup of morning coffee from your ration, thereby give the organism chance to have a rest from caffeine. Your organism will thank you in any case. For example by means of the glow of health.

It is necessary to shake up gel before using. By choosing the shower gel, give preference to those one, which is not aromatized or aromatized weakly: coffee gives it characteristic smell, but by their mixing can appear unpleasant slip.

It helps get pleasure out of exercises and decrease susceptibleness to pain, which hamper to continue trainings. The experiments, which were made by Victor Maridakis with collegians, have shown that drinking coffee for an hour before experiment with a peak load reduced pain by 48 %, with an average load – by 26%.

However, researchers warn about the careful use of caffeine, because high doses can cause anxiety by some people, as well as palpitation and sleep disturbance.

Extensive study of coffee influence on a mortality, where during a quarter of a century have taken part over 125 thousand of people, showed that people who had drunk more coffee have the most lowest dying risk of cardiovascular diseases. Moreover it does not matter whether coffee was full or decaffeinated.

Research people under the direction of Esther Lopez-Garcia of the Autonomous University of Madrid have taken an advantage of data from this extensive study about the impact of diet on mortality. Since 1980 till 2004, 84 214 women every two years have regularly reported to scientists about their habits in eating and drinking. In particular, they reported and the number of drunk coffee. Since 1986, else 41,736 men joined them. Participants of the study, who one and all were medical professions, have neither cancer nor heart diseases.

Results were summed up in 2004. By the end of the experiment have been died 18 thousands of participants – more than 11 thousands of women, and nearly 7 thousands of men. The cause of death for almost half of the women and about 35% of men was cancer. Cardiovascular diseases have killed around 20% of women and 30% of men.

After careful selection of other factors that may affect mortality, such as smoking, alcohol abuse and predilection for fatty foods, scientists were able to determine what contribution makes coffee on mortality.

This contribution turned out negative.
Among women who drank two to three cups of coffee per day, the death probability of heart disease was less at 25%, drank four to five cups of coffee – at 34%. The scientists had no success to observe neither positive nor negative impact on the development of cancer. Since cardiovascular diseases are a major cause of death, then the total mortality with the use of coffee was declined.

The results among men were even more encouraged – the more coffee they drank, the longer they managed to survive. For those study participants who rarely did without 5 cups of coffee per day, the death probability of cardiovascular diseases decreased by 44%! At that, there was not again discovered any relation to the development of cancer.

Cautious researchers, whose results were published in the prestigious Annals of Internal Medicine, are warning against too literal interpretation of these results. There is no need run to Barista and order ten cups at one draught.

First, the quantity of coffee was valued confessedly. And while they all were related to medicine, and therefore hardly to lie about their predilection to colleagues, it is impossible to exclude the possibility of inaccuracies in such the reports.

Secondly, like in all such studies, correlation does not prove cause-effect relation between two activities. Perhaps, the good health of itself as something related to the human desire to drink coffee, and perhaps invigorating drink to drink more precisely those who have to work so much that once and die.

Third, according to the authors of the latest work, previous studies as for this have shown different results. And while the authors of any of the previous works can not boast of such mass of participants or its duration, as Lopez-Garcia and her colleagues, independent confirmation is still needed.

Finally, the physiological causes, which could help to understand why coffee suddenly proved useful for the heart, were also not established. It is well-known that caffeine raises blood pressure quickly and thus only accelerates the cardiac muscle wear. So, this component is unlikely to have a positive effect – especially since, according to the results of Lopez-Garcia studies, decaffeinated drink yield a little to natural products in terms of reducing mortality. It may protect the heart some other components of coffee, which produce long-term positive effect.

Therefore, there is no need to abuse this drink.

By the way, in other article in the Journal of Agricultural and Food Chemistry turned it out, that if you want to invigorate, it is not always necessary to drink coffee. Its aroma itself can cause alterations of making albumens in the brain, changing the expression of at least 17 genes, which usually respond to the coffee.

Scientists from the Milan Institute made analysis of more than a dozen studies concerning liver cancer, where was stated the quantity of drunk coffee by competitors. Italian experts believe that substances contained in coffee, can block enzymes which promote cancer development. In addition, they found that caffeine is linked to lower risk of cirrhosis that often leads to cancer.

Earlier investigations, which were made by Japanese experts and had more than 90 000 people of older ages, showed that by people who drink coffee regularly, the risk of liver cancer fell by half, compared with those who had not used this drink.